Current Evidence for the Involvement of Hypogonadism and Modulation of Steroid Receptors in Prostate Carcinoma

Prostate cancer (PCa) is the most prevalent in Nigerian male population, similar to other black populations. It postulated that exposure endogenous or environmental steroids prompts prostatic mediated changes via steroid receptors as well a decrease androgen/estrogen ratio and aging. Thereby contributing carcinogenesis disease progression. This study aimed determine plasma levels of testosterone, 17β-estradiol pattern expression subjects with prostate cancer, benign hyperplasia, controls. Study participants are made up total 195 consented volunteers consisting 65 hyperplasia (BPH) treatment naïve apparently healthy Anthropometric data were measured using standard methods biochemical parameters determined by enzyme-linked immunosorbent assay (ELISA). The gene quantified Real-Time PCR PerfeCTa SYBR Green SuperMix on CFX96 Bio-Rad, USA. results this showed increased 17β-estradiol, androgen receptor (AR) estrogen receptor-beta (Erβ) compared controls (P<0.05). A Significant reduction testosterone BPH was observed (P<0.001). significantly PCa (p<0.05). We positive correlation between ERβ PSA group (r=0.32, p=0.02). There differential AR, ESR1 ESR2 studied group. shows hypogonadism an ERβ, AR cancer. suggests modulation these hormones their may be associated initiation progression could valuable interpretation kinetics stratification cases after screening.